r/AskReddit • u/IndependentTune3994 • 14h ago
What's a discovery that should have blown people's minds but somehow got a collective shrug from the world?
7.5k
u/TMellon_1899 12h ago
That almost all "recycled" plastic has always been burned and dumped, in global quantities that are absolutely mind boggling.
2.1k
u/Substantial_Pea3462 11h ago
I talk about this all the time and people either don’t believe me or don’t care. And whenever I go to throw away something plastic idk wtf I’m supposed to do with it. This one just makes me so fucking mad.
951
u/EjaculatingAracnids 9h ago
I work at a place that sends 6 dumpsters(8 yard capacity) filled with plastic waste to the landfill every single day. I stil put my recycling in the blue bin, clean up waste next to roads and try to do my part, but im not flagellating myself over small things that slip through the cracks.
→ More replies (6)150
u/neoKushan 2h ago
I used to work for an actual recycling company in Belfast, about 20 years ago. We'd bring our vans full of recycling goods back to the "yard" to be processed - we collected cardboard, paper, plastic, glass (Separated into clear and green/brown) and foil.
The plastic would get thrown into a big machine that condensed it down, as it takes up so much room. It spat out these cubes of plastic which were stacked in the yard like hay bales, quite high as well - I'd guess 4 or 5m high.
And that continued the whole time I was there - the glass, paper/cardboard and foil would get processed and taken away but the plastic just built up and built up, filling the yard over time.
The dumb thing is that we didn't just take any plastic, either. We pretty much only accepted plastic bottles, no butter cartons or takeaway tubs or anything like that. We had to reject anything that wasn't a plastic bottle, all just so we could compact it and pile it up to sit there.
Madness.
→ More replies (5)134
u/literallydogshit 2h ago
Not just sit there, but actively degrade via sunlight, which pretty much turns it directly into microplastics/nanoplastics blowing away in the wind.
→ More replies (3)456
u/SallyThinks 10h ago
I hate this so much, too. Even though I know it will all just go to the same trash dump, I still wash those mfs and put them in the bin. I can't bring myself to throw them away. I have enough plastic bottles filled with water in my basement to hydrate and bathe my entire neighborhood for at least a year 🤣
→ More replies (4)216
u/Devonai 10h ago
Except now we have to worry about microplastics.
→ More replies (6)190
u/Fourhundredbread 7h ago
Actually, realistically speaking, we probably don't need to worry about microplastics...cause they're already accumulating in every organ, in every person, in all of our oceans, in our soil, across the globe...and can't really be gotten rid of (afaik). So if they turn out to be heavily detrimental to our health, it really seems like it's too late to do anything about it.
→ More replies (8)91
u/Objective_Switch8332 5h ago
*For ourselves. We still need to worry for future generations, at least. And we can at least limit more exposure.
→ More replies (7)191
u/Bolognahole_Vers2 9h ago
I just try to buy less disposable plastic. Its why I don't have a Keurig machine. I feel al lot less guilty throwing wet paper in the garbage, than a plastic cup for every cup of coffee I drink.
→ More replies (5)90
u/JustaSeedGuy 8h ago
My roommate has a Keurig machine, and upon discovering the amount of waste behind it, but reusable cups. So now our coffee waste is near zero. No filter to be thrown away, no Keurig cup getting thrown away. The only waste is the electricity used to run the machine and the soap and water used to wash the cups
→ More replies (3)47
→ More replies (26)80
u/Curleysound 9h ago
It’s too big to rationalize. Like, yes, it’s clearly bad, but there’s nothing I can do about it. Now, you might say “yes there is, with a litany of efforts to start a movement to make a global change if people all just come together…” that’s not happening. I’m sorry. People can’t agree on anything in the group size we need for this. People couldn’t agree on going into a cave if an asteroid was coming. We can’t stop something like this from evolving without changing the entire structure of commerce
→ More replies (10)73
u/Schpyder 7h ago
The move to personalize recycling responsibility was literally propaganda from plastics manufacturers so that excessive plastic waste could be foisted off as a personal failing of the consumer rather than a structural problem to be addressed.
→ More replies (2)540
u/laughguy220 11h ago
But first it gets shipped to other countries, to add to the very environmentally friendly process.
→ More replies (3)121
u/WatercressBetter9892 9h ago
The most outrageous is that that system lasted as long as it did on the vibes and good PR.
And we all felt guilty filling the yogurt cups, yet we watched a massive amount being exported, stored, burned, or disposed of somewhere out of sight. Out of sight did a fair share of heavy lifting of consciences.
The magnitude of it ought to have elicited greater outrage than it did.
→ More replies (5)129
u/HC-Sama-7511 11h ago
This one really got me. One of a string of things in a row, where I was confronted with everyone just lying to me about something for my entire life.
→ More replies (3)→ More replies (47)59
u/Mysterious_Cat_7539 9h ago
Wait what?
→ More replies (7)207
u/SkittlesLentil 9h ago
Plastic is hard to recycle, and many containers are marked as recyclable even though they actually aren't. There's also still large parts of the US that don't have easy access to recycling. According to the article below, as of 2020 only 8% of plastic was recycled
→ More replies (9)94
u/Masrim 7h ago
It's not that they are hard to recycle, it is just not profitable to recycle them.
They could recycle them, but since it is outsourced to private corporations (on your tax dollar) to recycle, they chose the most profitable route which was incinerate it.
→ More replies (8)
1.9k
u/cambriansplooge 11h ago
The discovery of nitrogen-fixing organelles confirmed theories on the evolution of single celled life forms with implications on everything from extraplanetary research to farming. The other endosymbionts you've heard of are chloroplasts and mitochondria, we discovered a third.
Every discovery of plastic-degrading enzymes
445
u/1mnotklevr 10h ago
cant wait till those latter ones start eating the microplastics in human bodies
→ More replies (3)435
u/Affectionate-Bag8229 9h ago
Slowly but surely, people all around the world start failing breathalysers
People report being a little more tired and relaxed, before tests discover that microplastics broke down by this bacteria produce alcohol as a side effect and now everyone's just like 10% wasted at all times
203
u/blurpo85 9h ago
How is permanently making me tipsy only the second best thing these mofos do to my body?
→ More replies (1)→ More replies (15)61
u/Zip_Zoopity_Bop 8h ago
"Im sober enough to know what I'm doing, and drunk enough to enjoy doing it."
→ More replies (1)→ More replies (13)46
u/TeutobergForest 9h ago
Yo I want to read whatever paper this was published in, can you post a link? That's amazing
6.9k
u/JeffSergeant 12h ago edited 6h ago
The Panama Papers revealed a massive conspiracy of global tax evasion, no-one batted an eye.
The journalist who broke the story was quietly assassinated.
1.8k
u/TrioOfTerrors 11h ago
She was killed by a car bomb and a figure from the Maltese organized crime world is set to go on trial for it but it appears the wheels of Malta's justice system turn incredibly slow.
524
u/TrollTollTony 10h ago
If the wheel is still turning then it's faster than in my country.
→ More replies (2)82
u/RcoketWalrus 5h ago
I can't even guess the country you're from based on that comment. Is it the one that invades countries and protects pedophiles, or the other one that invades countries and protects pedophiles?
Mine is the one that invades countries and protects pedophiles.
→ More replies (1)15
→ More replies (2)365
u/Tasty_Dig8426 10h ago
yesss...
millions of leaked files of world leaders, Billionaires, Celebs.
real evidence that the crazy sums of money were being saved as everyone else pays taxes normally.
after she was gone the world just moved on.
and no one even questioned onee thinggg..
→ More replies (1)128
u/MeltingDog 4h ago
It happens on a smaller level, too.
Here in Australia an independent journalist/YouTuber revealed loads of corruption mainly around one guy in the local state government. There was so much material and evidence he basically released a video a week about it.
His house was firebombed (luckily he wasn't there at the time). The police eventually found the guy who did it and he admitted he was a hired thug. He was jailed...and that was it. The guy admitted he was a hired thug and no one asked "Who hired you?".
The biggest "news" outlet to pick up the story? Fucking twitch streamer MoistCr1TiKaL.
→ More replies (3)425
u/arriesgado 11h ago
Is there a venn diagram somewhere with Panama Papers people as one circle and people in the Epstein files as the other circle?
252
→ More replies (4)128
133
u/YaBoyJamba 11h ago
I'd guess this is because most people probably already assumed that it was going on and so it wasn't some mind blowing revelation to learn it was actually happening.
→ More replies (2)95
u/MildGenevaSuggestion 8h ago
Billionaires not paying taxes was about as breaking news as the Atlantic Ocean tasting salty.
540
u/ZeroRobot 12h ago
Not really true though. The European Union (EU) Anti-Money Laundering (AML) requirements were a direct and significant reaction to the Panama Papers so I wouldnt say ’no-one batted an eye’, it changed the whole financial sector in EU (for the worse if you ask me).
78
→ More replies (7)245
u/laughguy220 11h ago
The problem is, they apply them to us normals, the ultra rich couldn't have us knowing their tax saving secrets.
The ultra rich just moved on to the next scheme.
→ More replies (6)→ More replies (21)39
3.1k
u/endorrawitch 9h ago
The Japanese figured out how to REGROW TEETH.
And I’ve only seen a few little blurbs about it
879
u/Narrow_Spirit_4181 7h ago
A few separate times, I’ve bought Japanese toothpaste called Apagard, which apparently mimics tooth enamel and basically regrows your enamel or fills-in fissures. It was like $17 for two tubes, but you don’t know what having clean teeth is until you use it - i compare it to having your teeth waxed and polished. This reminds me that i need to get some.
40
u/Externalshipper7541 5h ago
https://pmc.ncbi.nlm.nih.gov/articles/PMC8930857/
I found a scientific article backing up the effects. It's not a crazy miracle drug, but it actually seems to be quite effective
→ More replies (1)→ More replies (22)170
u/themapleleaf6ix 7h ago
Where can you buy it from?
173
u/chaotic4059 6h ago
→ More replies (2)70
u/unwavering- 5h ago
Boka has same active ingredients! They sell at CVS and Amazon.
→ More replies (1)21
u/santikara 2h ago
percentage matters for this ingredient. iirc it's ideally supposed to be 10% and up, and boka won't share what theirs is. apagard has multiple variants and i assume the percentage is different in all of them.
→ More replies (4)200
606
u/short_and_floofy 8h ago
didn't they also just figure out how to regrow knee cartilage?
385
u/HawaiianPunchaNazi 8h ago
→ More replies (3)133
u/short_and_floofy 7h ago
i'm nearly at the point i'm gonna need knee replacement. really 🤞🏼 really hoping this is an available option before surgery is definitive
→ More replies (3)→ More replies (4)100
157
u/IncredibleBackpain93 8h ago
Nice! Im going to have a Drink for the japanese researchers later and hope they figure out how to regrow a liver soon. 👍
→ More replies (1)81
u/karbl058 7h ago
Livers already regrow naturally. That’s why you can donate a part of yours and both you and the recipient will be okay.
→ More replies (7)22
u/out_of_my_mind 5h ago
That's a popular, but untrue factoid. If part of the liver is removed, the remaining amount will take over function and enlarges, but it does not regrow and livers are not a renewable resource. Even after function is restored, it's still less resilient and capable than a full liver.
→ More replies (5)→ More replies (27)115
u/ckglle3lle 7h ago
Well this one didn't get a ton of buzz because it is still in the early stages. Passed animal trials but has yet to be seen in human trials and is still a long way from commercialization even if it does pass human trials. Even on the best case roadmap, it may still only be a treatment that is offered to certain people/conditions rather than a generic dentistry item.
It's also one of those topics that has come up multiple times over the decades and never actually manifested into a viable treatment. This latest research seems promising and is maybe the best yet but probably still many years minimum before we can really get excited about it
65
u/NewDistribution8509 7h ago
The first human clinical trial began in October 2024 at Kitano Hospital in Japan.
→ More replies (3)
981
u/VLKN 8h ago
I kinda feel like the invention and rollout of PrEP has been completely missed by anyone who isn’t gay. We literally have a drug, where if you take it regularly, you won’t get HIV. That’s a milestone that should be celebrated every day. Most people are just completely unaware that it exists.
→ More replies (8)326
u/iacuras 7h ago
Not just that, but the drastic improvement in HIV care over the last 20 years that have turned it from a death sentence to something easily treated with a single daily pill.
66
u/captain_linguine 3h ago
Plus PeP for post exposure cases and the fact that we now know that if someone who is positive has an undetectable viral load they will not transmit HIV at all.
→ More replies (3)→ More replies (7)39
881
u/Thick_Caterpillar379 8h ago
The discovery that should have changed everything is Social Baseline Theory (SBT).
Through a mental health and neurobiological lens, SBT proves that the human brain does not view being alone as a "neutral" state. Instead, our brains are biologically hardwired to expect the presence of others to help manage our mental and metabolic costs. When you are with someone you trust, your brain literally shuts down certain threat-response regions, "outsourcing" its stress regulation to your social circle.
Essentially, social connection isn't just a "nice to have" or a social lubricant; it is a primary biological resource as vital as calories or oxygen. When we are isolated, our brains have to work significantly harder to "render" and monitor the world for threats, leading to a state of constant, high-load metabolic strain. This suggests that many mental health struggles like anxiety and depression are not just "internal glitches," but predictable biological responses to a lack of social support.
The world largely gave this a collective shrug because the implications are deeply inconvenient. Acknowledging SBT would require us to admit that our modern culture of hyper-individualism is biologically nonsensical. It’s much easier for society to tell an individual to "practice self-care" than it is to admit that our current way of living in isolated suburban boxes or staring at screens, is a public health crisis that physically wears out the human brain.
111
u/Anothernamelesacount 6h ago
Absolutely fascinating. Thank you, friend, I didnt knew jack about this and its wonderful. Once again, science proves that having a community is good for you.
→ More replies (27)67
1.2k
u/RealisticPersimmon 12h ago
New classes of antibiotics- and thank fucking God for them
346
u/Monster_Dumps_2026 12h ago
Yea. We were in track for something nasty. Like not being able to do surgery nasty
170
u/Scholarsandquestions 11h ago
Hold on, are you saying we earned some more time with working antibiotics?
40
u/SCastleRelics 8h ago
For now 😈
27
→ More replies (2)58
u/Aikenova 10h ago
Like the other guy said: please come back! I'm intrigued. Whatchu mean we were in for something?
174
u/HalfWineRS 10h ago edited 10h ago
Eventually they would stop working as pathogens become resistant to each antibiotic. Everytime you take antibiotics they're just that little bit less effective as they kill most cells, but a few cells survive the attack, and now know how to defend against it. These now resistant cells reproduce and can spread to new people, who won't be able to treat it with antibiotics.
These are called 'super bugs' and this is why it's important to take ALL your antibiotics even if you feel better after a day or two.
So now if we found something completely different to what we have, all the bugs have zero resistance
Edit: Not to mention all the antibiotics fed to commercially farmed animals, largely cows/beef. So even if you're never sick you are still potentially building up a resistance to antibiotics through your diet.
92
u/Tavarin 7h ago edited 3h ago
We are fortunately finding that as most bacteria become more resistant to currently used antibiotics, they are becoming less resistant to old antibiotics like penicillin. So as bacteria become more resistant to current antibiotics, we may be able to cycle back to old antibiotics, and keep rotating them as resistances evolve.
→ More replies (2)25
u/Separate-Presence-61 8h ago
Theres been a proposed solution to the antibiotic resistance problem since the late 90s: modified bacteriophages.
These viruses only attack bacteria, and are very effective at it. Bacteria are so small that the limit to their genetic make-up is actually a physical constraint; not enough space for all the DNA. They have to choose whether to maintain genes that resist phages or antibiotics, but they can't do both.
The most dangerous antibiotic resistant bacteria are the most vulnerable to phages. Over time those bacteria would have to trade their antibiotic resistance for phage resistance, and you could just switch back and forth between the different treatments over time to stay ahead of any resistance.
It doesn't mean we are out of the clear yet though, as treatment-resistant fungi is potentially just as dangerous and there's no immediate counter to them.
→ More replies (1)27
u/JesseCuster40 9h ago
Things like this are what make me thankful the world is full of people far more intelligent than me. I'm just trying to make it through the work week, and people are out there creating new antibiotics.
→ More replies (1)→ More replies (8)45
100
u/alexromo 6h ago
The pancreatic cancer dude who got ridiculed for his birthmark instead of praise for his discovery
→ More replies (1)
1.2k
u/CovertButtTouch 8h ago
We were weeks away from a global cyber attack that would have compromised most electronic devices across the internet. An organization (experts think Russia) spent years planning an attack where they planted a master code into ssh. It was caught in beta and was weeks away from being deployed. This happened months ago and no major news outlets seemed to even cover it.
202
207
→ More replies (13)142
u/Strupnick 7h ago
Achtewally ☝️🤓This happened a couple years ago. But yeah it was an incredibly sophisticated attack. The veritasium video goes into extreme detail and explains all of the related components and history in an easy to understand way. Read watch for anyone who has a passing interest in the topic
→ More replies (1)
507
u/DangleDagger420 7h ago
Trees communicate with each other. It's crazy! They communicate through underground fungal networks. They share nutrients, warn each other of threats and even feed other dying trees. Nobody is talking about this.
84
u/Hyperbol3bee 7h ago
Everybody should be talking about this!
→ More replies (3)187
u/scbalazs 6h ago
Well, I’m sure the trees are
→ More replies (1)15
u/mikethet 2h ago
"Hey Bob, did you hear the humans have finally worked out we can talk to each other?"
""Jeez that took them long enough. How's the family anyway? The kids must be over 50ft tall now"
→ More replies (20)22
u/dog_in_the_vent 5h ago
This completely blew my mind when I learned it and I want to piggyback on your post.
Aspen groves are all the same tree. Each aspen that you see in a grove shares the same DNA with all of the other aspens. It's all one connected organism with the same root structure, sharing the same nutrients.
→ More replies (3)
896
u/Spekpannenkoek 10h ago
The first steam ‘engines’ already exist in Roman times but were more seen as a a neat party trick or a novelty rather than something useful.
Just a reminder something as groundbreaking as the Industrial Revolution was more than just the mechanism itself.
→ More replies (32)241
u/JesseCuster40 9h ago
Bit like the lightbulb. Inventing something and then making it affordable/usable are 2 different things.
→ More replies (5)
2.2k
u/PinkDoe 13h ago
it's pretty obvious but the Epstein files. Each release is more vile and incriminating. But folks are still not angry enough.
324
u/weekend_cam 11h ago
I think it's not just the Epstein files in terms of how disgusting they are, but the level of access and to world leaders and intelligence he had
→ More replies (2)31
u/Throwawayyoursynths 3h ago
Exactly. Not only the disgusting details, but how the elite actually operate and communicate with each other. How they view humanity. The things they believe and how they plan to manipulate the world. They’re all basically 13 year old edgelord boys who think they’re super deep and philosophical, except they have the money, influence, and power to enact their dumb ideas.
469
u/ModularWhiteGuy 11h ago
I'd add to that - Asmongold read out part of a bank statement that strongly implied that Epstein "won" the powerball lottery and used that through a trust to buy the zorro ranch.
So are people just doing a collective megashrug about the impossibility of him winning the lottery versus powerball actually being a funding mechanism for large scale CSA?
Is nobody curious enough to follow the money and look into the people that control Powerball to figure out how the jackpot got funneled into Epstein's trust account?
170
u/bbsnek731 8h ago
Attorney in NM (aka where Zorro Ranch is), and I know people do not pay attention to our state often except when something really random and terrible happens here (eg, Baldwin case, atomic bomb, Gene Hackman's death, etc.), but if anyone follows our congressional members and our state government, I can tell you that they are not only some of the few politicians that have stood and continue to stand on business when it comes to Epstein, but they are also some of the only ones following the money... and anything else related to that property. The ABQ Journal and the Santa Fe New Mexican (side note: two of the few remaining local papers that are still independently owned), they have a bunch of articles about zorro ranch.
→ More replies (2)45
→ More replies (20)131
96
59
u/xtremechaos93 10h ago
This as a victim of CSA myself I'm disgusted at the injustice that is happening in my country these people need to pay for their crimes
→ More replies (1)20
→ More replies (20)134
u/mrmonster459 10h ago
The silence over the Epstein files is what broke any last remaining hope I had for MAGA supporters.
Now, in hindsight it was foolish to ever have even a bit of hope for them after January 6th, bribing Stormy Daniels with campaign dollars, the "grab em by the p****y" comments, etc. But I was so hoping that if anything could possibly be bad enough to break their allegiance to him, it would be this.
→ More replies (1)83
u/nocowwife 9h ago
My mother in-law refused to vote for anyone but Trump because the Dems were pedos. Radio silence about Epstein.
→ More replies (3)
2.1k
u/Badloss 10h ago
mRNA vaccines are like this generation's moon landing. They are a staggering scientific achievement and the gateway to curing all kinds of diseases, and instead of developing this technology we're abandoning vaccines entirely and killing our children with measles
795
u/Own_Bet5189 9h ago
And trying to ban the use of mRNA at the state level. It's infuriating. I hate MAGA so much for all the evil they have caused.
→ More replies (8)74
u/tunisia3507 7h ago
mRNA vaccines are quite highly rated but massively underrated. The fundamental research was done for years beforehand, but when push came to shove the researchers were just like "shall we work over the weekend and knock out a covid vaccine?". It was literally a weekend job to go from no treatment to a safe, well-targeted, and effective vaccine for a pandemic which was crushing the world's economies and killing millions. That's some sci-fi MCU nonsense. You could catch a cold and have a vaccine ready for that specific strain before you stop sneezing.
→ More replies (1)→ More replies (20)221
u/brtbr-rah99 9h ago
Oddest thing is it happened on Cheeto Jesus’s watch. Not only did he not try to take credit for it, like he does for things he’s not tangentially involved in, he actively tried to sabotage it. He’s so fucking stupid it boggles the imagination.
→ More replies (2)149
u/MildGenevaSuggestion 8h ago
He did try to take credit for a while. He only stopped when he realized the antivaxxers were overwhelmingly MAGA and got booed at his rallies when he brings up how fast he got a vaccine made.
→ More replies (2)
259
u/Affectionate_Hornet7 6h ago
I really thought the stuff Edward Snowden risked his life to tell us should have concerned people a lot more.
→ More replies (5)
205
u/stardog_champ13 7h ago
That in one lifetime - HIV was discovered and was basically a death sentence for anyone who contracted it. Within 45 years, treatment has evolved to where people can easily live with it and get to undetectable levels. Insane we 'cured' (I don't know a better word for it) a nearly 100% fatal disease in a single lifetime.
→ More replies (2)
3.6k
u/Advanced_Savings_163 14h ago
The guy in Portugal that has recently cured pancreatic cancer in mice and needs money to be to develop a cure for humans. He should be able to spend his time thinking, not begging for money. Sorry, forgot his name.
1.0k
u/SerMarron 13h ago
Mariano Barbacid
344
→ More replies (1)79
338
u/Mindless-Baker-7757 11h ago
No no. I work in oncology. All kinds of mouse cures out there. When it passes phase 2 trail it's worth paying attention to.
→ More replies (6)84
u/ArenSteele 9h ago
Yay it cured mouse cancer! Then the mouse died of natural causes before the super deadly side effects could kick in!
80
u/pyronius 9h ago
More like, "Yay! I cured cancer in a mouse! After causing cancer in a mouse! Turns out, the trick was to give it cancerdote number 8, the antidote to the canceronium that I used to create the model!"
Note: I have worked in research and I know that this is a super dumb simplified version of the problem. But there is a real problem with research that creates a model and then cures that model. Which isn't always the fault of the researcher. It's just that creating a good model organism is extremely difficult and doesn't generally translate well once you start trying it in human subjects. If you want a good model that translates well into humans without just throwing shit at the board and seeing what sticks, then you basically have to study the issue at hand in humans so thoroughly that by the time you start testing a cure, you'll already be fairly certain that it's going to work because you know the issue inside and out.
→ More replies (1)→ More replies (39)498
u/MatCauthonsHat 12h ago
It's a mouse trial. Like 90% of mouse trials never translate to humans. Don't get too excited
601
u/BitcoinMD 11h ago
We have cured so many things in mice. We are living in like the golden age of mouse health care
→ More replies (5)241
u/unafraidrabbit 11h ago
And mouse genocide.
42
u/justonemom14 11h ago
Well, we could probably have great human health care too, if it were ethical to breed and kill them arbitrarily, and also if we had the insanely early sexual maturity and short lifespan of mice.
→ More replies (2)→ More replies (2)35
u/I_fail_at_memes 11h ago
To make an omelette…
→ More replies (1)68
228
u/PlacatedPlatypus 11h ago edited 11h ago
I am a cancer researcher and have read the source publication (here for anyone curious). It's very promising and convincingly shows that concomitantly knocking out three specific targets at once puts a large majority of pancreatic cancers into remission with no record of recurrence over a long period. Generalizability looks good and they go as far as patient-derived xenografts which have equivalent response.
The major caveat is not that it's in mice, it's that none of the three targets are currently drugged. It remains to be seen if they can be drugged, but if they were easy to drug, it would've been done by now.
One has an alternate target that seems to work just as well that is drugged but even if that is a sufficient substitute, two targets still remain.
If/when all three targets are drugged, I actually have good faith that this could become a first-line therapy.
→ More replies (15)28
u/Plus_Spirit_8632 11h ago
May I ask where they find so many mice with pancreatic cancer? Or do they somehow… make them have it?
34
u/Chidoriyama 10h ago
Mouse cancer machine sounds cartoonishly evil but also the logical answer to your question
→ More replies (1)36
u/PlacatedPlatypus 10h ago
Iirc, the authors did a pretty comprehensive study with four different ways of inducing cancer.
GEM (genetically engineered mice), where a mouse has some genetic modifications that make it susceptible to a certain cancer to such a degree that it is guaranteed to develop it.
Cell culture, where tumor cells are grown in a dish without a host organism
Orthotopic injection, where cancer cells are implanted directly into otherwise healthy mice to induce cancer development.
Patient-derived xenograft, where human cancer cells are implanted into heavily immunodeficient mice (to avoid rejection of human cells), so they develop human-like tumors.
→ More replies (3)54
→ More replies (10)39
260
u/CrazyWhammer 9h ago edited 7h ago
mRNA vaccines. These are a major leap forward for vaccine manufacturing, enabling companies to adapt quickly to new viral strains. They also have favorable safety profiles and no, they don’t change your DNA.
→ More replies (1)
1.0k
u/TpinTip 13h ago
We literally detected gravitational waves - ripples in spacetime - and everyone went back to arguing online.
→ More replies (98)142
u/richarizard 12h ago
As someone who actively loves reading and learning about physics, I'm confused by this one. We've known for a very long time that gravity is very accurately modeled as "ripples in spacetime." That's the basic theory of general relativity: gravity is the geometric curvature of spacetime. That's what Einstein's field equations said from over 100 years ago. Did I miss something? Did the theory fundamentally change, or are you just referring to recent research around detections that are some of our strongest signals to date?
32
u/FRNKNSTNPNPTCN 5h ago
Because up until now, we could only observe its effects, but not detect it directly. Watching an apple fall to the ground is not observing gravity, you are merely observing the effects of gravity.
Consider that literally every single solitary piece of info we've been able to gather from space has ONLY come from one source: light. And in order to gather all the advanced knowledge from just the last century, we have had to understand how light works and operates. Imagine all the jobs and fields of study that exist purely to understand light, and all the ripple effects this has had on other seemingly unrelated fields.
Now there is a second thing we can detect. Gravity. Now try to imagine all the fields of science that are about to be invented because of this. There is a whole new branch of astronomy that has never existed before.
→ More replies (1)86
u/Thee_Sinner 8h ago
I think it was a “the math tells us this is possible” and then we actually detected it
477
u/Sean_theLeprachaun 10h ago
The material brought back from an asteroid (Bennu) older than earth, thats most likely from the seabed of a long destroyed planet, that contains the building blocks of life. Literally all life on earth could be the second genesis of life from a planet destroyed more than 5 billion years ago.
→ More replies (11)157
u/Ill_Job4090 8h ago
As far as I have read, thats still pretty much a speculation and far from substanciated in any way.
→ More replies (3)
74
u/NegotiationSea7008 8h ago
A giant leak of more than 11.5 million financial and legal records exposes a system that enables crime, corruption and wrongdoing, hidden by secretive offshore companies.
182
u/MaxwellHoot 9h ago
In 2024 an SSH encryption backdoor (presumed to be from Russia) had the potential to essentially wipe out 80% of the Internet. A German programmer named Andres Freund just happened to notice a tiny 0.05s slowdown on his computer, and from that, discovered that every version of those computers was compromised. Supercomputers, server farms, regular people all had this vulnerability. When it was discovered and solved, the media was just like “oh cool- good find random guy!”
Mainstream media isn’t really technologically literate enough to understand how severe this could have been. I’m talking planes falling out of the sky, banks failing, hospitals going dark all across the world. Like the crowdstrike bug on steroids. We were likely weeks away from this without even knowing it.
→ More replies (3)31
255
100
u/Mindless-Baker-7757 11h ago
The gravitational waves are pretty fucking cool. We knew they were there but to actually be listening to them is very very fucking cool
→ More replies (1)
379
u/20characterusername0 10h ago
We cloned a sheep in 1999.
Suspiciously, 27 years later, there has been no chatter about the successful cloning of humans.
Not “so and so went to jail for trying”; Not “The UN has unanimously passed this law permitting/forbidding human cloning by any country”; Not “They walk among us”…
Just silence.
And that part is weird to me.
160
u/thenerfviking 9h ago
There’s a general consensus in parts of the scientific community that China has probably already done it if it’s possible and just kept it under wraps or not talked about it if it didn’t work.
56
u/Lonesome_Pine 9h ago
I guess making people the old fashioned way is too much fun?
→ More replies (1)162
u/GrapeAyp 9h ago
Read “the house of the scorpion”
It is the focus of this exact topic and the implications for the rich.
Need a new liver? Grab one from your clone.
→ More replies (5)100
36
u/Silver-Winging-It 8h ago
Check out that Korean doctor in the 2000s that was scamming cloning ability. He was a fake but you did get chatter.
We've cloned lots of other animals (there's an industry with pets and race horses outside of conservation efforts) but human cloning is generally banned. Although it's likely China or another advanced country with a history of dubious science ethics is secretly trying
→ More replies (1)65
u/Narrow_Turnip_7129 9h ago
Someone did get prosecuted from China or something for completely misusing CRISPR.
→ More replies (1)26
→ More replies (15)64
u/MeanOrange9 9h ago
There’s no real benefit to a human clone other than like organ harvesting maybe. It’s not like it has your memories or anything it’s basically just your kid.
→ More replies (11)64
u/Call_Me_ZG 8h ago
Harvesting organs is probably a huge one (once you ignore the ethics of it all).
If if gives a 100% change of an organ match the billionaires are probably already in on it
→ More replies (5)
116
u/spicy_noodle_guy 8h ago
That the entire modern world was molded and shaped to be a playground for child eating rapists and they essentially don't care that we know.
→ More replies (1)
347
u/Undrcovrcloakndaggr 10h ago
There's this loosely connected club of utter c*nts with more money than is imaginable who control everything, routinely interfere in & influence elections home & abroad and love to bend rules to ensure they maintain power & dragon-level wealth... oh and they love to rape kids with impunity.
→ More replies (7)
25
91
u/seo-nerd-3000 9h ago
The discovery of microplastics in human blood, placentas, and basically every organ in our bodies should have been a civilization-altering wake-up call but instead we just kind of went huh that sucks and kept drinking from plastic bottles. We are literally finding plastic particles in newborn babies and the collective response has been shockingly muted. In 50 years we are going to look back at this the same way we look back at lead in gasoline and asbestos in buildings and wonder how we knew and still did nothing.
→ More replies (1)27
u/VestedNight 7h ago
And all three of these disasters were caused or exacerbated by the same ~3 companies.
→ More replies (2)
131
u/CamBearCookie 9h ago
That DuPont poisoned the whole world with microplastics and they're still allowed to do business. Children are being born with microplastics, it's in semen, and even in the soils of untouched areas in nature. I haven't seen so much as a class action lawsuit.
→ More replies (5)24
u/SantaRosa_WhiteSox 8h ago
This shit pops into my head on a regular basis and I still cant belive the underreaction
21
51
u/YankeetheGreater 6h ago
Handwashing.
A doctor implemented handwashing before we knew bacteria existed, and the mortality rate of his patients reduced significantly post surgery.
He was laughed at by his peers.
→ More replies (2)
181
u/Electronic-Plate-483 14h ago
First Image of a Black Hole
→ More replies (4)52
u/GraceGreenview 11h ago
It’s framed and autographed in our house. No joke.
→ More replies (5)87
u/Zokstone 11h ago
Wow you met the black hole? What was he like
→ More replies (2)147
u/Antiumbra 11h ago
Very attractive. Had a way of pulling in everyone around him.
→ More replies (3)
63
16
u/icleanjaxfl 5h ago
Scientists at the Lawrence Livermore National Laboratory in California officially achieved a major nuclear fusion breakthrough—known as ignition or scientific energy breakeven on December 5, 2022.
80
u/strawberryaudit 9h ago
The fact that the we proved your gut bacteria can influence mood and anxiety and everyone just went cool and kept stress-eating gas station snacks.
Like… we basically confirmed there’s a second brain in your stomach and society responded with a probiotic yogurt commercial and moved on.
Feels wildly under-hyped for something that can literally change how you feel day to day.
→ More replies (5)17
u/the_grand_apartment 5h ago
The difference in how you feel just by changing your diet is unbelievable. Up until December I had been eating basically garbage my entire life. Had a health scare and the hospital dietician got me on a high-fibre diet with loads of fruit and vegetables and gut-healthy foods like kimchi and other fermented goods. I'm still lazy AF but the change in my mental health is literally night and day.
192
u/pyeritanical 9h ago
The US government was found liable in civil court for the assassination of MLK Jr. King's family was given a settlement but no government official or agency has ever been charged criminally
→ More replies (2)36
u/slytherinprolly 5h ago edited 4h ago
They were not. Only Larry Jowers was found liable. US government was never sued nor named in the lawsuit. The lawsuit was against a sole person who once gave an interview where he claimed to have been part of the conspiracy to kill King and that government agencies were involved and they set up James Earl Ray as a patsy. The jury awarded the King family $100. Pretty much every claim made by Jowers has been overwhelmingly debunked. The King family won a stacked lawsuit against a crackpot who had no real ability to defend himself or aid in defense in civil court. There is a reason no one other than Jowers, especially any government agency, was named in the suit.
→ More replies (1)
87
15
u/schaudhery 2h ago
The people that are running the country collectively got together and molested a bunch of kids.
28
u/Direct-Map1553 11h ago
Human flight. Nobody seemed to care for several years, and even then, they could imagine some limited military use for it.
→ More replies (2)
7.0k
u/fredinNH 11h ago edited 11h ago
Bispecific antibodies to treat cancer.
Why? It’s not chemo so no bone damage, no increased risk of other cancers, no long-term neurological problems, no hair loss, no digestive problems. None of that. But, it’s more effective than chemo and easier to administer.
It’s already approved as a last option for some cancers and works incredibly well in that setting. There are numerous clinical trials happening right now designed to prove that it should replace chemo entirely for some cancers and they are figuring out how to use it for more cancers.
How do I know this? My wife got in an early clinical trial and it put her in deep remission with almost zero side effects. She’s back how she was 5 years ago. No weakness or diminishment at all.
Almost nobody seems to know anything about this.